In 1963, together with the construction of the Olaine Plastics Processing Factory, the construction of the central laboratory building of the Olaine Chemical Reagent Factory was started. The factory project was created by "Giprohimreaktiv" from Kharkov. Graduates of the 35^th Vocational Technical School and prisoners who worked under the supervision of construction specialists participated in the construction works. According to the project, the building of the central laboratory was intended as a four-story building with specially built laboratory rooms. Before the commissioning of the central laboratory building, the director of the factory was J. Staivo.

In 1965, the building of the central laboratory was put into operation. G. Gaišais became the director of the factory. After the completion of the construction works, the students of the 35^th Vocational Technical School arranged, washed and cleaned the premises of the factory’s central laboratory for days.

In 1966, the Olaine Chemical Reagent Factory commenced production. Boriss Ļebedevs, the former director of the Riga Cement Factory, became the director of the factory. The central laboratory of the plant put the first development into production in 1966, and by 1971 it had developed almost 500 preparations. On July 10, 1966, the plant’s itaconic acid workshop was put into operation. Itaconic acid was used in the production of synthetic detergents, and the one produced in Olaine was cheaper and of better quality.

In 1968, a workshop for biochemical preparations was put into operation, producing enzymes, proteins and other biochemical preparations for the food industry, medicine and the needs of microbiologists.

In 1972, the last large production building of the factory – the organic synthesis workshop – was put into operation. This workshop produced preparations of organic synthesis, which were used in research, medical industry, economy and agriculture.

The total area of the factory covered 17.2 ha, and apart from the production workshops, the factory had its own water treatment facilities, a block of auxiliary workshops, a nitrogen and oxygen station. A room with a peculiar name – “Vivarium" – was built next to the biochemical preparations production plant. The vivarium building was meant for keeping animals for scientific research, but since the factory did not conduct research with animals, dormitories for the factory’s engineering staff and workers were installed in the vivarium.

The factory regularly cooperated in the field of scientific research with scientific research institutes in Moscow, Leningrad and Riga in order to improve research work and obtain better results. The factory, unlike the other Olaine plants, not only produced, but also contributed greatly to the field of chemistry, molecular biology and genetic engineering. The factory also produced chemical preparations for the destruction of weeds in fields, which was a product in demand in collective farms and Soviet farms. Many scientists and scientific workers who worked on research were graduates of Olaines 35^th Vocational Technical School and many other universities and technical schools. Methods of obtaining chemical compounds were already studied before the factory workshops and the laboratory were put into operation.

On August 31, 1962, the Specialised Bureau of Designers was established for the development of the industrial production method of piperazine. In 1970, a patent department for scientific – technical and economic information was established in the factory, and Uldis Kauliņš was appointed as its head. The task of the department was the identification of new preparations, the search for methods of acquisition and the preparation of informative materials. The department organised scientific conferences, meetings and other events. The department had a wide library of scientific literature, the task of which was to supply engineers and technical workers with scientific and technical literature. In 1985, the library had 10 000 items of scientific literature. The scientific workers of the factory were from all over the Soviet Union. Some of the employees had graduated from universities of the Latvian SSR – UL, LUA, RPI (Riga Polytechnic Institute). 

In the early eighties, in the itaconic acid workshop research was conducted to replace sugar with a cheaper material, but the research was not completed, because in 1990 the production of itaconic acid was discontinued. The central laboratory of the factory was equipped with the most modern foreign equipment and facilities for analysis and research. In the research work, the factory also cooperated with other institutes and organisations that worked on the basis of contracts for the needs of the scientific research of the factory. Such outsourcing had a big disadvantage – “leakage of production secrets”. The production of Phenibut can be mentioned as one of the precedents. In this regard, the Supreme Council of the USSR was involved, which helped to strengthen the copyright of this substance. A patent and rationalisation working group was created at the factory, which was later transformed into a department. The department successfully protected the intellectual property rights of the factory, and by 1990 the factory had received 512 patents for the products it created. Scientific employees of the plant wrote scientific publications in newspapers, scientific magazines, and created conference materials. By 1990, 1 220 scientific works had been published.

In addition to research, the factory also increased production volumes. In 1979, the organic synthesis workshop produced production in the amount of 10.3 million roubles. In 1979, the profit of the products produced at the Biochemical Preparations Workshop was 6.6 million roubles. The amounts of raw materials used in production are enormous. Mainly food products are used. In the period from 1966 to 1978 44.6 tons of bread yeast, 2 million eggs, 30 tons of pig blood, 4.5 tons of animal kidneys and sugar were used in production.

In 1988, the factory’s production rates dropped sharply. In 1988, ZRA "Biolar" production rates were reduced to 75 tons. In 1991, the range of manufactured products decreased rapidly. In 1992, ZRA "Biolar" became the Latvian state company "Biolar".